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KMID : 0043320090320010075
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Archives of Pharmacal Research
2009 Volume.32 No. 1 p.75 ~ p.78
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In vitro Anti-inflammatory Activity of Carvacrol: Inhibitory Effect on COX-2 Catalyzed Prostaglandin E2 Biosynthesis
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Marsik Petr
Vanek Tomas
Pribylova Marie
Kokoska Ladislav
Landa Premysl
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Abstract
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Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E2 catalysed by COX-2 with an IC50 value of 0.8 μM what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 μM and 0.8 μM, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 μM for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.
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KEYWORD
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Carvacrol, Cyclooxygenase, Prostaglandin, Inhibition, Anti-inflammatory
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